Laxatives liquid3/6/2024 PEG-3350 was mixed with a starch-based pre-thickened juice. One case report was identified where a patient was switched to a thickened diet for dysphagia. The Institute for Safe Medication Practices (ISMP) Canada issued a Safety Bulletin discussing the possible potential harmful interaction between PEG laxative and starch-based thickeners. Reports of a potentially harmful interactive effect The recommendation to use a thickener should be based on the patient’s degree of dysphagia (and potential risk of aspiration), the desired consistency required, the texture required, palatability, and other clinical considerations (see guidance from the Specialist Pharmacist Service). There are many different brands of thickeners available and they can be in the form of powder or a liquid. Most thickeners are classified as foods for special medicinal purposes and are used to thicken both liquids and foods to various consistencies. There are two main types of thickening agents – a starch-based (for example, corn-starch) or a gum-based (xanthan gum). Thickening the liquid before swallowing improves bolus control and reduces the risk of aspiration, which can be life-threatening. Thickened liquids are usually taken by patients with dysphagia, including people who are elderly or have disabilities that affect swallowing. Some PEG laxative products such as Movicol, Macrogol 3350, and Moviprep are available in the form of a powder, which must be dissolved in liquid before administration. They are indicated mostly for adults with some formulations also indicated for use in children. Polyethylene glycol (PEG) laxative products treat constipation through an osmotic effect. report suspected adverse drug reactions (ADRs) to the Yellow Card schemeĪbout polyethylene glycol (PEG) laxatives.avoid directly mixing together PEG laxatives and starch-based thickeners, especially in patients with dysphagia who are considered at risk of aspiration such as elderly people and people with disabilities that affect swallowing.combining the two compounds can counteract the thickening action and result in a thin watery liquid - patients with swallowing difficulties (dysphagia) are potentially at greater risk of aspiration of the thinner liquid.there have been reports of a possible potential harmful interaction between polyethylene glycol (PEG) laxatives and starch-based thickeners when they are mixed together.
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